Supramolecular Structure and Antimicrobial Activity of Ni(II) Complexes with s-Triazine/Hydrazine Type Ligand

The two complexes, [Ni(DPPT)2](NO3)2*1.5H2O (1) and [Ni(DPPT)(NO3)Cl].EtOH (2), were synthesized using the self-assembly of (E)-2,4-di(piperidin-1-yl)-6-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-1,3,5-triazine (DPPT) with Ni(NO3)2*6H2O in absence presence NiCl2*6H2O, respectively. In both cases, neutral tridentate DPPT ligand is found coordinated to Ni(II) via three N-atoms from hydrazone, pyridine s-triazine rings. Hence, homoleptic complex 1 has a NiN6 hexa-coordination environment while NO3− are counter anions addition one-and-a-half crystallized hydration water molecules acting as an outer sphere. heteroleptic 2 NiN3O2Cl coordination sphere where completed by one bidentate nitrate chloride ion leading inner contains ethanol molecule. Both complexes have distorted octahedral environments around ion. Using Hirshfeld analysis, intermolecular contacts H…H O…H Cl…H, O…H, N…H, H…H, C…H C…C be most important for crystal stability. antimicrobial activity was assessed against different bacterial fungal strains, results compared free well antibacterial (Gentamycin) antifungal (Ketoconazole) positive controls. better agents than ligand. Interestingly, similar C. albicans Ketoconazole.